Six months following the conclusion of "Nemesis: Reign of Darkness Volume I" a new vampire power rises from ancient history and takes control of the vampire leadership, pushing forward and changing the agenda previously begun. The DSA task force continues their struggle to oppose the vampires and end the threat of their takeover of both the United States and the world. As the Nemesis, Alex Chance, grows stronger and more capable, he finds more allies and a contingent of survivors, feline lycanthropes, and others to assist in their efforts. They see an end in sight, but the ending is anything but what they envisioned.