The second edition of this book focuses on the unambiguous identification of lesions in the endocrine system of laboratory animals, a base which is expanded to include new information coming from contemporary techniques, such as invoking mechanisms of action of xenobiotics, identification of cells by their ultrastructure and secretory products, and recognition of effects of toxins on cells and tissues. New methods, applicable to answer a pathologist's questions, are, for example, offered for the study of the hypothalamus and its controlling influence on all endocrine organs. Contemporary concepts of each endocrine organ of laboratory animals and other species are considered and presented in detail, superbly illustrated with gross, histologic, and ultrastructural figures. A basic handbook in toxicologic pathology for the pathologist at the beginning or peak of his or her career, it is also of value to any biologic scientist.