Published in 1888, "The Legacy of Cain" is the final novel completed by Wilkie Collins. The novel explores the theme of hereditary evil, and attacks the idea that 'bad blood' necessarily results in a criminality.

Eunice and Helena are sisters brought up by their father, the Reverend Abel Gracedieu. They grow up quietly and happily, until some dark secrets about their past come to light. One of the daughters is adopted: her mother was executed for murdering her husband. When the murdered husband's mistress and brother both enter the picture, a series of events is set into motion to finally reveal the truth. Which of the two young women must confront her difficult heritage?