This study is to explore the practices and attitudes of mobile learning for university students studying at Guangzhou-based on a theoretical model of the Framework for the Rational Analysis of Mobile Education (FRAME) model, in particular, to explore what and how knowledge will be acquired by using the mobile device for formal and informal learning. This study provides many Guangzhoüs university students using a mobile device for formal and informal learning strategies. Then, this study shows that Guangzhoüs university students positive attitude for mobile learning, and they believed mobile learning can facilitate their learning performance. However, this study cannot find any evidence to support higher quality mobile device may affect positive learning performance and attitude.