The story of Fred the Fly and Some of His Friends relates to a period when Fred enters an open window of a house and settles on the side of a jug of cream. His anticipation at being able to sample some of that cream is swiftly ended when he is hit by the mistress of the house with a rolled-up newspaper. Fred hides behind the window blind, recovering from the attack. But when another swish from the mistress sends the blind crashing down, Fred is thrown into a container of potato peelings and other vegetables. This begins his journey to the top of the garden and a whole new adventure involving his enemy, Sam the spider, and his friends Cedric the slug and Harry the snail.