Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals.
This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on chemical mutagens and carcinogens. It synthesizes the body of knowledge and recent advances in this rapidly emerging field through the contributions of leading experts from around the world.

Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens focuses on the use of QSAR modeling in predicting and designing compounds for synthesis and testing of cancer drugs. The authors clearly show how QSAR can contribute to the elucidation of mechanisms, to identifying toxic chemicals solely by their chemical structure, and to the design of safer chemicals. The contents include a general introduction to QSAR theory and extensive reviews of virtually all existing QSAR models.

Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens provides the first comprehensive, interdisciplinary summary of QSAR studies on chemical mutagens and carcinogens. It focuses on the use of QSAR modeling in predicting and designing compounds for synthesis and testing of cancer drugs and in identifying toxic chemicals solely by their chemical structure. Also presented are new approaches to QSAR modeling that can reduce the use of animals in lab testing. While chemists, biologists, and toxicologists will find this book useful, it also contains background information on the principles of QSAR, making it a suitable resource for newcomers in the field.

"[T]he editor has assembled a first-rate team of contributors who are themselves active in the field ? . ? I can certainly recommend this volume on the basis of the information it contains ? . " - Journal of Medicinal Chemistry, 2004, Vol. 47, No. 21